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Impairment in Function and Expression of Transient Receptor Potential Vanilloid Type 4 in Dahl Salt-
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http://hyper.ahajournals.org/cgi/content/short/55/4/1018?rss...
Submitted by cardiologylinks 4 months, 1 week, 5 days, 8 hours ago
To examine the role of transient receptor potential vanilloid type 4 (TRPV4) channels in the development of salt-sensitive hypertension, male Dahl salt-sensitive (DS) and -resistant (DR) rats were fed a low-salt (LS) or high-salt (HS) diet for 3 weeks. DS-HS but not DR-HS rats developed hypertension. 4-Phorbol-12,13-didecanoate (a selective TRPV4 activator; 2...
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